The Number of Registered Candidates in Congress: 4667 People
The salivary beta-2microglobulin (β2m) and prostate-specific antigen (psa) can be used as an alternative to the serum β2m and psa for diagnosis and monitoring of prostate diseases
1. Department of Biochemistry and Genetic, Faculty of Medicine, Arak University of Medical Sciences, Arak, IR. Iran. 2. Department of Biochemistryand Genetic, Faculty of Medicine, Arak University of Medical Sciences, Arak, IR Iran
Abstract
Introduction
In recent years, the use of saliva as a specimen, due to its non-invasive and easy access increased. but their roles have not been confirmed yet. therefore, our aim was to evaluate the correlation between salivary, serum beta-2microglobulin (β2m) and prostate-specific antigen (psa) ratio in patients with prostate diseases.
Methods
This case control study included 20 prostate cancer (pca) patients and 20 benign prostatic hyperplasia (bph) patients. the β2m and psa levels in their saliva and serum were measured with the enzyme-linked immunosorbent assay. the derived data was compared using the mann–whitney u test. the correlation between salivary and serum β2m / psa was determined using spearman’s correlation test.
Results
Significant differences were observed between the pca and bph groups in terms of the β2m and psa levels in the serum and saliva (p < 0.001). the correlation was positively and significantly between salivary and serum β2m in pca and bph groups (r = 0.747, p < 0.05) and (r = 0.513, p < 0.05) respectively. as well as, the salivary psa in the pca (r = 0.610, p < 0.05) and bph (r = 0.531, p < 0.05) groups is positively and significantly associated with the serum psa in the two groups.
Conclusion
According to the results of the present study, the salivary β2m and psa can be used as an alternative to the serum β2m and psa for diagnosis and monitoring of prostate diseases.
