1. Department of Biotechnology, Shahid Beheshti University 2. Department of Animal Biology, University of Tabriz 3. Department of Medical Genetics, University of Social Welfare and Rehabilitation Sciences 4. Department of Ecophysiology, University of Tabriz 5. Department of Animal Biology, University of Tabriz
Abstract
Introduction
Diabetes mellitus (dm), a metabolic disorder is a major public health problem in both developed and developing countries. dm increases risk of several serious health problems or complications including hyperlipidemia, poor metabolic control, nephropathy, hepatopathy. so this study was to investigate the probable nephroprotective effect of loe in the alloxan-induced diabetic models.
Methods
Twenty eight male albino wistar rats were randomly divided into four groups as following: healthy control group (hc) receive saline (0.9 % i.p.)during the experimental days; diabetic group (dc) receive single i.p. administration of alloxan (120mg/kg b.w); first dose treatment group (ft) received a single dose of alloxan (120mg/kg) and loe (100mg/kg b.w) i.p. for 21 consecutive days and second dose treatment group (st) receive single dose of alloxan (120mg/kg) and loe (200mg/kg b.w) i.p. for 21 days.
Results
All diminished level of mda, sod, cat, urea and creatinine in treated diabetic models showned the nephroprotective activity of loe.
Conclusion
High potential antioxidant and neproprotective effect of loe.
