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Frequency of tet resistance gene and tem beta-lactamase resistance genes in the normal flora of the intestines of addicted people without symptoms of intestinal infection and diarrhea, iran-ahvaz city
1. Department of Biology, Faculty of Basic Sciences, Islamic Azad University of Ghiamdasht (East Tehran Brach), Tehran, Ira 2. Department of Biology, Faculty of Basic Sciences, Islamic Azad University of Ghiamdasht (East Tehran Brach), Tehran, Ira 3. Department of Microbiology, Karaj Branch, Islamic Azad University, Karaj, IR Iran.
Abstract
Introduction
Wide studies in national institute for drug abuse(usa) are done with preventive goals, or risk and protective factors associated with abuse, and improving and expanding community perceptions.antibiotic resistance e.coli is an intestinal and intestinal inflammatory agent in humans.
Methods
The basis of the study is to compare the resistance of bacteria (e.coli) in the stool of addicted and non-addicted persons.rapid diagnosis of primary addiction was done by rapid method.ultimately,the patient's addiction was proved by thin-layer chromatography. stool sample was taken from these individuals and 16 antibiotic drugs + 2 resistance genes (tem - tet) were used for microbiological and molecular tests.
Results
Antibiogram of bacterial specimens extracted from stool samples of two groups showed high frequency of drug resistance in normal bacteria in addicted individuals. in this case, the average drug resistance in the addict group was 4.6 times higher than the control group. also, the frequency of tem and tet resistance genes was higher in addict persons stools
Conclusion
The bacterial resistance is higher in the phenotypic and genetic findings of the addict's stool, and perhaps the intestinal flora of addicts can be an epidemic source of infectious diseases due to the presence of bacterial resistance genes
Keywords
Addiction
enterobacteriaceae
resistance antibiotic
tem betalactamase gene
tet resistance gene
