1. Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences 2. Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences 3. Department of Chemistry, College of Sciences, Shiraz University
Abstract
Introduction
Graphene is a multifunctional carbon nanomaterial and could be utilized to develop platform technologies for cancer therapies. it can covalently and noncovalently bound with anticancer drugs and functional groups that target cancer cells and tissue to improve treatment efficacies. targeted drug delivery has become important, attractive and challenging in biomedical science and applications. graphene, a sp2 hybridized two dimensional lattice of carbon atoms arranged in a hexagonal structure, has become one of the most sought-after nanotechnological wonder of the past decade, the underlying reason being its distinct structure and exceptional physical properties. on the other hand, cyclodextrins (cds) are oligosaccharides composed of glucose units, which are toroidal in shape with a hydrophobic inner cavity and a hydrophilic exterior. these interesting characteristics can enable them to bind selectively various organic, inorganic and biological guest molecules into their cavities to form stable host guest inclusion complexes or nanostructured supra molecular assemblies in their hydrophobic cavity.
Methods
-graphite was oxidized to go and was interact with phenylalanine amino acid. then cd was attached to the modified graphene via ester bonds.
-doxorubicin hydrochloride (dox) as an anti-tumor drug model was loaded onto the surface of bionanocomposites.
-cytotoxicity of bionanocomposite was evaluated on mcf-7 breast cancer cells.
-dox release was examined in various phs.
Results
-bionanocomposite was characterized by ft-ir, xrd, tga, raman and fe-sem.
-the loading efficiency of dox on bionanocomposite was 426 μg/mg
-higher cytotoxicity of dox-bionanocomposite was seen against mcf7 cells.
Conclusion
Dox-bionanocomposite exhibits remarkably higher loading capacity compared go and the drug release depends strongly on ph values. improved efficacy of targeted dox-loaded nanocarrier was observed compared go and free dox.
Keywords
Graphene, bionanocomposite, anti-cancer drug delivery, cyclodextrin
