Endometriosis is a chronic disease that is characterized by the occurrence of endometrial glands and stroma outside the uterine cavity. endometriosis seems to be the result of a complex interaction between environmental factors and various genes. in this regard, the cytochrome subfamily 17 (cyp17) may play an important role by altering the biosynthesis of sex steroids. cyp2c19 is also an important member of the cytochrome p450 family, and related mutations may result in an inability to fully metabolize environmental chemicals and cytokines, leading to several diseases. the aim of this study was to investigate the association of rs11592737 (a/g) polymorphism of cyp2c19 gene with the risk of endometriosis in iranian women.
Methods
100 patients with endometriosis and 100 controls with no laparoscopic evidence of endometriosis were included in this study. samples were analyzed for rs11592737 (a/g) single nucleotide polymorphism (snp) in cyp2c19 gene using amplification refractory mutation system-polymerase chain reaction (arms-pcr).
Results
Our data revealed a significant difference in the distribution of rs11592737 genotypes between endometriosis patients and controls (p=0.002). despite gg genotype, ag genotype was more frequent in patients than the control samples (p<0.001, or=3.14, 95% ci 1.66-5.96). significantly, those cases with a allele showed an increased risk of endometriosis compared to the control group (p=0.02, or=1.63, 95%ci1.08-2.44). no significant difference in the allele frequency has been seen in the different stages of endometriosis (p value=0.59).
Conclusion
The results of this study suggest that rs11592737 (a/g) of cyp2c19 may be associated with a higher risk of endometriosis among iranian population.
