These days, due to antibiotic resistance in bacteria, scientists are eager to find new generation drugs. lantibiotics are a group of antibacterial products containing lantionin amino acid which are mostly produced by gram-positive bacteria. these peptides are highly potential to tackle with resistant bacteria. this group of bacteriocins has attracted much attention in recent years due to the success of the well characterized lantibiotic, nisin, as a food preservative. the aim of this study is getting an introduction of new antimicrobial drugs.
Methods
All the reported researches related to lantibiotics and the antibacterial effects are studied and mentioned in this review.
Results
The lantibiotics are containing unusual amino acids, such as dehydrated and lanthionine residues. according to presented researches, lantibiotics which are a group of ribosomally synthesised, post-translationally modified peptides attack to lipid ii and prevent the cell wall synthesis to resist away bacteria. nisin is the first known lantibiotic that has been studied a lot and due to its widespread using the food industries, no side effects or microbial resistance has been reported yet.
Conclusion
Lantibiotics are peptides that exhibit antimicrobial properties and have a high potential to tackle with resistant bacteria. the properties of these substances have made it suitable to replace them with antibiotics. these antimicrobial compounds can also be used in food packaging to prevent food corruption and the growth of bacteria producing toxins. however, the clinical use of them requires more extensive research.
