1. urmia university 2. urmia university 3. urmia university
Abstract
Introduction
Studies have indicated that reduced energy consumption mostly has a significant effect on the reduction of blood lipids. also, hyperprolactinemia caused by reduced levels of dopamine in the brain, lead to impairing lipid metabolism. the purpose of this study was to investigate the role of dopamine d2 receptors in regulating the serum lipid profile in male rats under food restrictions (fr).
Methods
In this research, 42 male wistar rats were placed in 7 groups. the groups comprised of control, sham, sulpiride receiver (60µg/rat, icv), and groups with 25%, 50% and 75% fr, and the group with 75% fr received sulpiride which were treated for 21 days. serum samples of the animals were collected in order to measure the lipid profile, including, ldl and hdl, evaluated by electrochemiluminescence method. data were analyzed by one-way anova.
Results
Fr of 25% and 75% caused significant reduction of cholesterol and triglyceride levels in serum of the animals (p˂0.05), while fr of 50% significantly increased these factors (p˂0.05). fr at any rate did not cause any significant effect on serum levels of ldl and hdl. intracerebroventricular injection of sulpiride in male rats with free diet and 75% fr significantly caused more reduction of cholesterol and triglyceride, reduction of hdl and increase of ldl, respectively in comparison with the control groups and the 75% group.
Conclusion
Inhibition of dopamine d2 receptors led to improved cholesterol and triglyceride levels, however, caused ldl and hdl level disorder in the serum of rats under fr.
