The relationship between serum creatinine and creatinine clearance with the occurrence and severity of coronary artery disease

Zahra Ghafouri,1,* Mehdi rasouli,2 Babak bagheri,3 Najmeh radmard,4

1. Department of Clinical Biochemistry, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Mazandaran, I
2. Department of Clinical Biochemistry, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Mazandaran, I
4. Department of Clinical Biochemistry, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Mazandaran, I

Abstract

Introduction

Cardiovascular diseases are thought to be the most important reason of mortality around the world. among them coronary artery disease (cad) seems to associated to more than 250 risk factors. in the current cross-sectional study, the correlation of serum creatinine, creatinine clearance as well as other cardiovascular risk factors were investigated relative to the occurrence and severity of cad in 260 clinically stable angiographic documented patients aged 40 to 70 years.

Methods

: subjects with one or more lesions that narrowed the lumen of any coronary artery significantly (70%) were considered to be cad cases, whereas those without any narrowing (<10%) were taken as controls. serum creatinine, creatinine clearance, urea, lipid profile and sugar status were determined by laboratory biochemical kits. anthropometric parameters were collected by questionnaire.

Results

The levels of serum creatinine showed a significant increase in cad patients relative to control group (1.07  0.50 mg/dl vs. 0.95  0.21, p 0.008). moreover, the levels of creatinine clearance showed a significant decrease in cad patients relative to control group (78.5  36.6 vs. 94.3  20.8, p 0.001). serum creatinine and creatinine clearance were associated significantly with the occurrence and severity of cad in the unconditional univariate logistic regression analysis (or=1.79), whereas in conditional multivariate analysis, creatinine was removed from the equation with the entry of variables like sex, age and diabetes.

Conclusion

The results suggest that serum creatinine and creatinine clearance have a significant correlation with cad as potential risk factors, but in an independent way.

Keywords

Coronary artery disease, serum creatinine, creatinine clearance,