Relationship of pre-body mass index with umbilical coiling index in gestational diabetes and non-gestational diabetes mellitus.

Laily Najafi,1,* Mojtaba malek,2 Mohammad e. khamseh,3 Azadeh abedini,4 Maryam kadivar,5

1. Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences
2. Research Center for prevention of cardiovascular disease, Institute of Endocrinology and Metabolism, Iran University of
3. Research Center for prevention of cardiovascular disease, Institute of Endocrinology and Metabolism, Iran University
4. Kamali Teaching hospital, Alborz University of Medical sciences
5. Department of Pathology, Hazrat-e- Rasool Akram General hospital, Iran University of Medical Sciences

Abstract

Introduction

It has been well documented that overweight or obesity before pregnancy is a strong predictor of gestational diabetes mellitus [gdm].coiling as a unique feature of the human umbilical cord, is probably one of the most frequently reported umbilical cord related parameters in high risk pregnancies.ultrasonography evaluation of the umbilical coiling index [uci] could predict abnormal uci.the aim of this study was to assess the relationship between antenatal and postnatal uci and pre-body mass index[pre-bmi] in gdm and non-gdm pregnancy.

Methods

In our prospective study;117 gdm and105 non-gdm pregnancy. gestational diabetes mellitus was confirmed for the parturient at 24-28 weeks of gestation. an anatomical ultrasound survey of placenta and umbilical cord performed at 18-23 and 37-41 weeks of gestation (wg). a postnatal uci[puci] as reference standard was evaluated macroscopically within 24 hours after delivery. the umbilical cord coiling was quantitatively assessed using uci.

Results

At 18-23 wg,the median (quartile1-3) of uci in both groups were as follows: gdm(0.25(0.17,0.34)), and non-gdm (0.30(0.20,0.44)) respectively. this value at 37-41 wg was (0.21(0.19,0.31)) in gdm, and (0.27 (0.20,0.35)) in non-gdm groups respectively.in postnatal evaluation, the uci values in both groups were: gdm(0.18(0.14,0.26)) and non-gdm pregnancy(0.19(0.15,0.24)) respectively. correlation coefficient between pre-bmi and antenatal (2nd and 3rd trimester) and puci in gdm were 0.08,0.06 and 0.16(p-value=0.39,0.51 and 0.08). correlation coefficient between pre-bmi and antenatal (2nd and 3rd trimester) and puci in non-gdm were 0.07,0.17 and 0.12 (p-value=0.51,0.08 and 0.20).

Conclusion

No significant relationship was detected between pre-bmi and antenatal uci evaluations of both trimesters in gdm and non-gdm groups. also no significant relationship was detected between pre-bmi and postnatal uci evaluation in both gdm and non-gdm groups.

Keywords

Pre-bmi,gdm,uci