Determining the interactions between major dietary patterns and lrp5 genotypes (rs556442) on bone discordance in postmenopausal women referred to shariati hospital

Leila Khorraminezhad,1 Sajjad moradi,2 Zhila maghbooli,3 Sima aliakbari,4 Khadijeh mirzaei,5,*

1. Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sci
2. Department of Nutrition, Isfahan University of Medical Sciences
3. Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sci
4. Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sci
5. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (

Abstract

Introduction

one of the challenges in the diagnosis of osteoporosis is bone discordance. many studies have confirmed an association between major dietary patterns and the genes related to osteoporosis. this study aimed to evaluate the relationship between dietary patterns and bone discordance among low-density lipoprotein receptor related protein 5, which is one of the most important genes involved in bone metabolism.

Methods

in this study, 258 postmenopausal women were examined. measurement of bone mineral density (bmd) was carried out by the dual-x-ray absorptiometry measurement (dexa) method. a food frequency questionnaire (ffq-147-item) was used to determine dietary patterns. genotype frequencies of lrp5 (rs556442) were analyzed by rflp-pcr.

Results

Participants were categorized into two groups: bone concordance (53.4%) and bone discordance (42.8%). the bone discordance group had higher bmi (p =0.013) and fat mass (p =0.045) values. three dietary patterns were extracted, namely, unhealthy, mediterranean and western patterns. genotype frequencies of aa, ag, and gg were: 43.13%, 12.56%, and 43.30%, respectively. evaluation showed that there was no relationship between bone discordance and dietary patterns and the lrp5 genotype. a multiple regression model showed that women with gg genotype who followed the unhealthy dietary pattern were at higher risk of major bone discordance (β =1.87, p=0.003).

Conclusion

based on these results, it was seen that there were no associations between bone discordance and dietary patterns or lrp5 genotypes, but it was found that women with gg genotype who followed the unhealthy dietary pattern were at a higher risk of major bone discordance.

Keywords

Dietary pattern, nutrigenomics, lrp5, bone discordance