Association study of rs369770942 of neuregulin1 gene 3'utr with schizophrenia

Mahtash Malekian,1 Zahra noormohammadi,2,* Iman salahshouri far,3 Niloofar mahdavi hazave,4

1. Department of Genetics, Faculty of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
2. Department of Genetics, Faculty of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
3. Department of Genetics, Faculty of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
4. Department of Psychiatry, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Abstract

Introduction

: schizophrenia is a mental disorder and affects approximately 1% of global population. this study suggests that rs369770942 in the 3'utr region of nrg1 gene can be related to schizophrenia.

Methods

Blood samples were collected from 102 patients with schizophrenia referred to the psychiatric ward of imam hussein hospital and 506 army hospital in tehran and approved by the psychiatrist. blood samples from 113 healthy people were selected in a coordinated manner with patients. the genomic dna was extracted with using of salting out method and pcr-rflp was used to check polymorphism. chi-square statistical analysis used to check allele and genotype frequency, and demographic characteristics.

Results

: rs369770942 in 3'utr of nrg1 gene was anesthetized (aa) in case and control group, and there was no statistically significant difference between case and control groups. 66% of patients had occupational dysfunction and 86.2% of them didn’t have university education. there was a significant difference between case and control groups in the occupational and educational status (p = 0/000). 89.2% of patients had partial response to treatment and 2.9% had complete response to treatment. 26.5% of patients had a family history of mental disorders. a significant number of case and control group were of fars ethnicity and people of azeri ethnicity in patients were more than healthy people. 41.6% of patients had smoking, and there was a significant difference (p = 0.000).

Conclusion

Our results indicate that rs369770942 in the 3'utr of the nrg1 gene isn’t involved in the risk of schizophrenia.

Keywords

Neuregulin-1, mir-125a-3p, single nucleotide polymorphism, schizophrenia