Dna nanorobot: a novel approach for cancer therapy

Zohreh Bahadori,1,* Ali-akbar shaebani,2 Zahra hosseini-khah,3 Jahangir sabzevari,4

1. Dept. & Center for Biotechnology Research, Semnan university of Medical sciences, Semnan, Iran.
2. Dept. & Center for Biotechnology Research, Semnan university of Medical sciences, Semnan, Iran.
3. Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Science, Tehran, Iran
4. Department of Microbiology and Microbial Biotechnology, School of Biological sciences and Technology, Beheshti University, Tehran, Iran

Abstract

Introduction

Traditional treatments of cancer kill both healthy and tumor cells and cause hair loss, fatigue, nausea, depression, etc. dna nanorobot is an emerging field of nanotechnology which is a controllable machine at the molecule or nanoscale. so it moves inside the human body and affects specifically. dna origami nanorobots are potential intelligent drug delivery systems that are able to respond to molecular triggers. the aim of this review is briefly describing the architecture of the nanorobots and their role in the treatment of solid tumors.

Methods

This is a review essay.

Results

Dna origami can be formed by folding a long ssdna, called a scaffold strand, aided by multiple short dna oligonucleotides, which are called staple strands. this nanorobotic system can transport molecular payloads to cells, sense cell surface inputs for conditional activation, and also can reconfigure its structure for payload delivery. there are in vitro and in vivo studies which have tested the effect of nanorobots on tumor-associated endothelial cells and have shown that this device activates coagulation at the tumor site. the nanorobots induce intravascular thrombosis, resulting in tumor necrosis and tumor growth inhibition without immunologically harmful reactions.

Conclusion

Recent data have shown that dna nanorobots represent a promising approach for precise drug delivery in cancer therapy which target and destroy the cancer cells without touching the healthy ones.

Keywords

Dna nanorobots, cancer therapy, origami, nanotechnology