Background: early in the twentieth century, the first microbe-cidal and-static drugs were identified. the clinical use of antibiotics was initiated mid-twentieth century after the discovery of penicillin. however and quite soon, it was documented that microbes broadly developed resistance to antimicrobial drugs. this prompted research into the discovery of new antibiotics or research aimed to develop prophylactic and therapeutic approaches differing from the straightforward use of antibiotics. thus began a race between drugs and microbes that has continued into modern day and has culminated in the recent detection of bacterial strains that are essentially resistant against all clinically useful antimicrobial agents. treatments that were simple and successful in the past have now been compromised; 70 years ago penicillin could be universally used in the treatment of infections caused by staphylococcus aureus, now penicillin is ineffective in the vast majority of staphylococcal infections. it is believed by many and accepted by most that this scenario will apply to any classical antibiotic that enters the market, effectiveness will be limited until microbes have developed a or more ways around the static or cidal effects.
Methods
The study was a cross-sectional descriptive epidemiologic study in order to investigate the prevalence of microorganisms in b/c and csf in patients admitted to golestan hospital of ahwaz. this retrospective study was conducted for 12 months in patients. the study population included patients admitted to all parts of the golestan educational hospital who were suspected to have an infection in the blood or cerebrospinal fluid, standard samples from patients for the detection of microorganisms.
Results
All microorganisms resisted at least one drug in three classes of antibiotics (or more). except for staphylococcus aureus, which showed only the csf and klebsiella in the b/c of this resistance, all of the microorganisms tested in the blood and csf were resistant, so monitoring the use of antibiotics and the determination of multi-drug resistant strains it can prevent the development of resistance to bacteria
Conclusion
All microorganisms resisted at least one drug in three classes of antibiotics (or more). except for staphylococcus aureus, which showed only the csf and klebsiella in the b/c of this resistance, all of the microorganisms tested in the blood and csf were resistant, so monitoring the use of antibiotics and the determination of multi-drug resistant strains it can prevent the development of resistance to bacteria.
