Frequency of hla-b15 allele in spondyloarthritis patients

Narges Mohammadi,1,* Dr.sina mirzaahmadi,2 Somayeh gholami,3 Fateme modhejiyan,4

1. Department of Genetic group, Zanjan Branch, Islamic University, Zanjan,Iran
2. Department of Genetic group, Zanjan Branch, Islamic University, Zanjan,Iran
3. Department of Genetic group, Zanjan Branch, Islamic University, Zanjan,Iran
4. Department of Genetic group, Zanjan Branch, Islamic University, Zanjan,Iran

Abstract

Introduction

Spondyloarthritis (spa) includes a group of chronic inflammatory diseases that have similar clinical symptoms, radiological findings, hla-b27 dependence and positive family occurance. different type of spondyloarthritis include: 1. anklosing spondylitis(as) 2. reactive arthritis (rea) 3. psoriatic arthritis (psa) 4. arthritis accompanied by bowel inflamation (ibd). in general, the symptoms include inflammation of the spine, side joints, tendons, and ligaments (antsitis) as well as inflammation in the skeletal muscles, skin, mucous membranes, bowel and eyes. hla-b15 has been detected to play an important role in some autoimmune diseases, but the effect of this allele, which is in fact an extensive antigen and divided into several separate antigens is unknown on spa. we are going to study the effect of these alleles on spondyloarthritis.

Methods

A total of 130 people, 100 suffering from spondyloarthritis ,and 30 healthy people with no occurence of the disease in their families were selected. the pcr test was used to identify the hla-b15 allele and the results were analyzed under significance level of 0.05 and using spss software.

Results

The results showed that 18 out of 100 patients (15 female and 3 male) and 1 out of healthy people (male) had hla-b15 allele (p-value = 0.03) and due to the p value, it seems that there is a significant relationship between the disease and hla-b15 allele. also, the sex is associated with existence of this allele and occurence of spa disease and presence of this allele as a predisposing allele is an important factor.

Conclusion

We studied spa patients based on the essg criteria and according to this criteria there was a meaningful relationship between hla-b15 and spa. also, the sex is related with existence of this allele and occurance of the disease, and when the patients show spa symptoms based on the essg criteria, the hla-b15 should be taken into consideration.

Keywords

Spondyloarthritis, hla-b15, essg, pcr