Vesico-ureteral reflux (vur) is one of the most common diseases
encountered by urologists. ureteral re-implant has been the only method of surgery for vur correction.
in recent years endoscopic injection of several agents (bulking agents) has been proposed as a treatment.
the aim of this study was to evaluate the therapeutic efficacy of endoscopic subureteric injection of total
blood nucleated cells and platelet
Methods
A clinical trial was done in 17 patients with vur aging 18-35 years
old in mashhad imam reza hospital, iran, 2012-2015. the participants were randomly selected and
placed under endoscopic injection following voiding cystourethrography (vcug). three months later the
patients were evaluated using clinical findings, urine culture and vcug. if the vur persisted, the second
injection was performed three months after the first one
Results
There were 17 patients including 13 females and 4 males, mean age 22.8 ± 4.9 years.
the procedure achieved success in 89% of renal units after the first injection and 94% after the second
one. we observed no major complications
Conclusion
Our pilot interventional clinical trial showed that endoscopic injection of total
blood nucleated cells and platelets is an effective method for treatment of vur in adult patients
