Study of chromosomal abnormalities and prevalence of consanguineous marriages in couples with recurrent spontaneous abortions (rsa) in ardabil province
The spontaneous abortion of the fetus is due to the loss of it until the twentieth week of pregnancy that is one of the most common medical problems during pregnancy. approximately 15 to 20 percent of all clinically recognizable pregnancies lead to abortion. failure in pregnancy involves economic costs and physical and mental for the family and the society. recurrent spontaneous abortion is a multifactorial phenomenon and this study analyzes chromosomal abnormalities and the prevalence of consanguineous marriages in parents with recurrent spontaneous abortions in ardabil province.
Methods
350 patients with at least two spontaneous abortions of the fetus were analyzed using gtg-banding cytogenetic technique.
Results
Parents chromosomal abnormalities were found in 18 cases (10.28% of couples). most of abnormalities were structural (72.2%). chromosomal aberrations were found in 10 (55.6%) females and 8 (44.4%) males. translocations were the most common chromosomal abnormalities (55.6 %) detected in this study. also, a significant correlation was found between recurrent spontaneous abortion due to consanguineous marriage and chromosomal abnormalities (p<0.05).
Conclusion
According to the significant correlation between recurrent spontaneous abortion and chromosomal abnormalities in this study and previous ones, and also the high rate of consanguineous marriages in ardabil province population, analysis of chromosomal abnormalities after genetic counseling is necessary for both parents with recurrent spontaneous abortions.
