1. Tehran University Medical Science 2. Tehran University Medical Science
Abstract
Introduction
Although many types of research have been developed that help identify human gene function but it should be noted that the function of many genes is still unknown. one of them is spermatogenesis associated-19 (spata19) which, so far only 11 articles have been published about it. spata19 is a testis-specific gene that has a mitochondrial signal peptide at its n-terminus. previous data has shown that spata19 has a high expression in the testis, and it has also been demonstrated the increase its expression in the basal cell carcinoma of the skin and in some other cancers, such as breast and prostate cancers. to understand the function of genes in in-vivo condition, transgenic animals are helpful. of these animals, mice have a wider use for different reasons such as evolutionary and genetic proximity to humans. by knocking out the mouse gene, behavioral, apparent, physical and biochemical changes can be made that can help to better understand the gene s function.
Methods
Recently, we replicated the spata19 mice for another experiment.
Results
Accidentally, we observed solid metastatic tumors originated from the armpit in transgenic mice. the gender of the affected mice was female. most of them had a history of labor and showed a lower life expectancy than others. pathologic diagnosis of these tumors was hyperplasia of the lymph nodes with very severe necrosis.
Conclusion
Causes of every tumor can be genetic or environmental. but it can be said that the influence or the lack of influence of environmental factors is also somehow influenced by genetic factors. it is possible that the immune system of these mice is weaker and the spata91 function is not limited to male fertility. of course, proof of these claims requires more research and research.
