1. Departments of Molecular and Cellular Biology, Faculty of Basic Sciences and Advanced Technologies in Biology, University of Science and Culture 2. Departments of Molecular and Cellular Biology, Faculty of Basic Sciences and Advanced Technologies in Biology, University of Science and Culture, Iranian Biological Resource Center (IBRC) 3. Royan Institute,, Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center,ACECR 4. Iranian Biological Resource Center (IBRC)
Abstract
Introduction
Preterm delivery (ptd) is one of the most significant contributors to neonatal morbidity and mortality. the etiology of preterm delivery is unclear. it is thought to be a multifactorial, complex disorder,, genetic and environmental factors. methylenetetrahydrofolate reductase gene is one of the genetic factors in women with preterm delivery. this study aimed to investigate the association between the methylenetetrahydrofolate reductase (mthfr) c677t polymorphism and preterm delivery susceptibility.
Methods
A total of 40 preterm delivery cases and 40 term delivery cases were studied for mthfr c677t polymorphism. statistical analysis was perforformed using spss software. the relevant risk of preterm delivery was represented by odds ratios (ors) with 95% confidence intervals (95% cls).
Results
Based on the results of this study, ct gene type frequency of c677t was higher in cases than controls (p.value=0.003). whereas, tt gene type had a lower distribution in cases than the controls (p.value=0.27). in addition, there was no significant relationship between t allele and preterm delivery. in addition, there was no significant relationship between t allele and preterm delivery ( p.value=0.069).
Conclusion
The results of this study demonstrated that gene type ct of mthfr c677t polymorphism might make preterm delivery risk rise in iranian women.
