1. Tehran university of medical science 2. Tehran university of medical science
Abstract
Introduction
In alzheimer's disease there is a extensive brain inflammation.studies showed that conditioned media derived from adipose tissue mesanchymal stem cell (ascm) has ant-inflammatory effects. for this reason we used it to attenuate inflammation in alzheimer model rats.
Methods
For induction alzheimer we used intrahyppocampal injection. then we injected i.p 0.2ml conditioned medium for 7 days in rats. in 7th day we extracted brain and made slice then measured tnf-a and il-1b as inflammatory factor via elisa
Results
We observed that in alzheimer model level of tnf-a and il-1b increased and in treatment group this factors decreased.
Conclusion
This study showed that ascm could reduce inflammation in alzheimer.
