The association study of rs13381800 in promoter flanking site of tcf4 gene and schizophrenia among iranian schizophrenic patients

Mohadeseh Agahi,1 Zahra noormohammadi,2,* Iman salahshourifar,3 Niloufar mahdavi hezaveh,4

1. Departmnet of Biology, Science and Research Branch,Islamic Azad University, Tehran, Iran
2. Departmnet of Biology, Science and Research Branch,Islamic Azad University, Tehran, Iran
3. Departmnet of Biology, Science and Research Branch,Islamic Azad University, Tehran, Iran
4. Shaheed Beheshti University of Medical Sciences, Tehran, Iran

Abstract

Introduction

Schizophrenia is an acute mental disorder and many molecular studies are done to find variation in genes causing schizophrenia. one of the significant candidate genes is transcription factor 4 (tcf4)

Methods

In the present study, the analysis of the association between rs13381800 located in promoter flanking site of tcf4 gene and schizophrenia was performed by the pcr-rflp method with a sample number of 100 patients and 101 healthy individuals

Results

The results showed 0.09 of cc genotype frequency in tcf4 gene in case group of the current study while its alleles frequency was not reported for any similar races in dbsnp. chi-square test of the polymorphism showed no meaningful difference between case and control group for rs13381800 (p=0.38) and the results also represented no existence of a meaningful difference between patient individuals with cc or tt genotypes in the case of sex (p=0.912), smoking (p=0.595), (p=0.451) and treatment response (p=0.714)

Conclusion

The current population was not in hardy-weinberg equilibrium so no models could be predicted for the alleles. regarding the logistic regression result, no relationship between rs13381800 and schizophrenia were found. the study of the polymorphisms in tcf4 gene and their association with schizophrenia help us in a better understanding of this mental disorder and it can be useful for designing new treatments for the schizophrenia in the future

Keywords

Schizophrenia, polymorphism, tcf4, rs13381800 , snp