1. Department of pharmacology, school of pharmacy-international campus, Iran university of medical sciences, Tehran, Iran 2. Cognitive and Neuroscience Research Center (CNRC), Amir-Almomenin Hospital, Tehran Medical Sciences, Islamic Azad Univer 3. Cognitive and Neuroscience Research Center (CNRC), Amir-Almomenin Hospital, Tehran Medical Sciences, Islamic Azad Univer
Abstract
Introduction
Alzheimer’s disease (ad) is the world’s most familiar dementing illness. ad typical presentations are loss of memory and cognitive function. deposition of amyloid-beta peptide (aβ) in hippocampus is one of the well-validate biomarkers in pathogenesis of ad. neurodegeneration disease like alzheimer’s are not treated yet.
Methods
In current study the effect of orally administration of salvia macilenta in the catalase activity of aβ-injected male albino wistar rats was determined. the plant’s aerial parts were air-dried, protected from direct sunlight, and then powdered. rats were received oral salvia macilenta (50mg/kg/day) for 10 days and then some of them received aβ (10 ng/µl) in their hippocampus (ca1 region). catalase activity was measured spectrophotometrically at 240 nm using h2o2 (0.01 m) as substrate, which was added to the cuvette at the end of the process.
Results
Data obtained from this study showed that in the aβ-injected group the catalase activity was decreased about %20 while orally administration of salvia macilenta extract increased it (1.3 folds) in the rats which received aβ compared to the aβ-injected group in the hippocampus region of the brain
Conclusion
Catalase is a very important enzyme in protecting the cell from oxidative damage by reactive oxygen species (ros). orally treatment of s. macilenta extract in aβ-injected rats could increase catalase activity so it can be one of proposed treatment for people suffer from ad model.
