The long non-coding rnas; a new trend in molecular biology ‎of infectious diseases

Reza Gheitasi,1,* Sanaz jourghasemi,2 Hamed manoochehry,3 Sara khosravi,4

1. MSc student of Immunology, Students Research Committee, Hamadan University of Medical Sciences, Hamadan, ‎Iran.‎
2. MSc student of Immunology, Students Research Committee, Hamadan University of Medical Sciences, Hamadan, ‎Iran.‎
3. ‎2. Ph.D. student of medical biotechnology, Students Research Committee, Hamadan University of Medical ‎Sciences, Hamada
4. MSc student of Microbiology, Students Research Committee, Hamadan University of Medical Sciences, Hamadan, ‎Iran.‎

Abstract

Introduction

‎ brucellosis is another example of infectious disease and one of the five most common zoonotic ‎bacteria in the world (1). evidence suggests that non-coding rnas undoubtedly have an ‎undeniable function in infectious disease, such as brucellosis. in these abnormalities, by use of ‎replacement or inhibition of non-coding rnas is emerging as a new novel way in treatment. in ‎this review, we focus on long non-coding rnas (lncrnas) that are involved in brucellosis (2). ‎we define the long noncoding rnas and indicate a brucellosis-inclined list of lncrnas, and ‎describe some of the role of lncrnas in infection (3), as well as current and future research ‎programs for lncrnas for the treatment of infectious disease, especially brucellosis.‎

Methods

Pubmed, scopus, and google scholar were searched from january 2013 to may 2018. based on ‎inclusion and exclusion criteria ten relevant experimental studies with moderate bias were ‎selected. the effect of long non-coding rna new player in brucellosis was evaluated. ‎

Results

Our analysis showed that the presently available evidence confirmed the therapeutic potential ‎of lncrnas in significantly inhibition and improvement of brucellosis symptoms. ‎

Conclusion

Lncrnas are an emerging field of investigation as they are suggested to regulate key biological ‎processes, including cellular proliferation and differentiation, and their aberrant expression is ‎strongly associated with infectious disease (4). an improved understanding of the role of ‎ncrnas in brucellosis would provide valuable information about key infection-promoting ‎pathways and might be highly useful for diagnostic and prognostic assessments (3). this ‎knowledge might also lead to advancement in the management of brucellosis through the ‎development of novel personalized ncrna-based therapies.‎

Keywords

Lncrnas, new marker, infectious disease, zoonotic bacteria, brucellosis