Investigation of the therapeutic effect of iranian native plants extract on human fungal pathogens: review study

Fatemeh Sadeghi,1,* Fatemeh peymaei,2 Taher elmi,3

1. Department of Medical Mycology and Parasitology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
2. Department of Medical Mycology and Parasitology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
3. Department of Medical Mycology and Parasitology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Abstract

Introduction

in recent years, due to the emergence of antifungal- resistant fungal species and these side effects, it is essential to use of the new antifungal compounds to overcome this challenge. hence, researchers are seeking new therapies for treatment of fungal infections. herbal extracts have attracted a great deal of researchers attention, due to their anti-fungal properties.therefore, in this study, we investigated the therapeutic effect of iranian native plants extract on human fungal pathogens.

Methods

In the present study, the collection of materials was carried out through the search of human fungal pathogens and iranian native plants extract in the google, pubmed, sid, iran medex databases.

Results

The results of the study (in vitro) showed that the aqueous extracts of anethum graveolens ,thymus vulgaris , coriandrum sativum and rosa damascena (at concentrations of 100, 250, 500, 750 mg / ml) on standard and isolated strains from aspergillus flavus and aspergillus fumigatus, reduced colony growth,( the effect increased with increasing the aqueous extracts concentration). in addition,the essence of thymus vulgaris, shariatian thyme, lavender, artemisia, cumin, sardinia and peppermint plants had very strong anti-candida activity and ,the essence of mountain rhizomes, black currant and herbs had strong anti-candida effects.while, the essence of eucalyptus, anisone, fennel, and geller showed medium anti-candida effects. on the other hand, trichophyton schonenleinii and trichophyton verrucosum were sensitive to all prepared dilutions of echinophora platyloba plant (at concentrations of 35, 50, 150, 250 mg / ml) and did not grow. while trichophyton mentagrophytes, microsporum canis and epidermophyton flucosum were only sensitive to 250 mg / ml dilution of the extract and resistant to the other dilutions. trichophyton violaceum was resistant to dilutions of 35 and 50 but was sensitive to increasing concentrations of the extract (150 and 250 mg / ml).

Conclusion

The findings of this study suggest that it is necessary to carry out more investigations on herbal extract in vivo. in this case we hope that it will be possible to achieve new compounds with low side effects for the treatment of fungal infections in the future.

Keywords

Plants extract, fungal pathogens, infections