The effect of human papillomavirus infection on the incidence and prognosis of squamous cell carcinoma of the tongue

The effect of human papillomavirus infection on the incidence and prognosis of squamous cell carcinoma of the tongue
fateme assar,¹ Farzane pardeshenas,^2,* parisa khorsand nouqabi,³ Hossein Bakhtiari-Dovvombaygi,⁴
1. Sudent omid Recearch group ,faculty of Basic Sciences ,Mashhad Islamic Azad University,Mashhad,Iran
2. Student omid Research group, School Of Nursery and Midwifery, Mashhad Islamic Azad University, Mashhad, Iran
3. Student omid Research group, School Of Nursery and Midwifery, Mashhad Islamic Azad University, Mashhad, Iran
4. Student omid Research group, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
Introduction: Squamous cell carcinoma of the tongue(TSCC) is the most common tumor of the oral cavity and the second most common tumor in the head and neck area and one of the ten leading causes of death in the world. It can cause white and red spots on the tongue.Alcohol abuse ,smoking,and oral sex(oral infection), are risk factor for TSCC. Human papillomavirus is the most common sexually transmitted infection, which is also transmitted through skin contact and can cause warts in various parts of the body. Today, about 40 different strains of this virus can spread to the mouth, throat, and the penis, which in severe cases can cause a variety of cancers of the oral cavity or Cervix.
Methods: This review was performed within articles published at PubMed, Google scholar, Cochrane and SID from 1992 to 2020. The keyword were HPV , Tongue squamous cell carcinoma. By searching this database, 51 articles were found,24of them were not related with investigating and 15of them by reading abstract were removed. All articles chosen from English and Persian articles.
Results: Finally, 12 articles were included in the study. 2 articles definitely showed a positive relationship between the history of HPV and increased risk of TSCC, but did not mention a significant relationship between the history of HPV and tumor graid, stage or lymph node involvement.Three articles emphasized that smoking and alcohol consumption are very important cause of scc of the tongue, And hpv is considered to be the only possible factor for TSCC that the only way to prevention، is to avoid risky behaviors such as (oral sex ) and Vaccine injection.Another study showed that patients with TSCC who have a positive history of HPV have a better prognosis than those with a negative history of HPV,so that they did not need chemotherapy or radiation therapy or needed less invasive treatment. The role of hpv in the prognosis of other oral cancers is currently unclear.
Conclusion: Since human papillomavirus infection is known to be a risk factor for TSCC, other studies indicate a good prognosis for TSCC in the presence of HPV infection. Therefore, further studies in this field and counseling with sexual partners are recommended for help to prevention and treatment of TSCC.
Keywords: HPV , Tongue squamous cell carcinoma