Bioelectromagnetic nanotranostic compounds based on photothermal therapy and magnetic resonance imaging.

Bioelectromagnetic nanotranostic compounds based on photothermal therapy and magnetic resonance imaging.
Samad hasani aghozi,^1,* Nasim jamshidi,² Yunus soleymani,³
1. Radiology Department, Paramedical Faculty, Tabriz University of Medical Science, Tabriz, Iran
2. Radiology Department, Paramedical Faculty, Tabriz University of Medical Science, Tabriz, Ira
3. Radiology Department, Paramedical Faculty, Tabriz University of Medical Science, Tabriz, Iran
Introduction: Common cancer treatment methods are chemotherapy and radiotherapy. However, these methods have significant side effects, so recently new treatments such as photothermal therapy have been considered clinically. Photothermal therapy has major advantages such as high efficiency and less damage to healthy tissues. This method uses electromagnetic light radiation (with wavelengths in the infrared region) besides nanoparticle absorbers with high efficiency of converting light into heat. Magnetic resonance imaging (MRI) is a non-invasive, non-ionizing modality in diagnostic imaging. MRI performance is significantly improved by contrast agents. The synthesis and application of tranostic compounds that have both the power to enhance the contrast in MRI and the ability to increase the conversion efficiency of light into heat is possible in the context of nanotechnology. These tranostic compounds, which have both diagnostic and therapeutic aspects at the same time, can be brought from potential to actual state, as another application of bioelectromagnetic in treatment of cancers, by using the electromagnetic waves of MRI.
Methods: In this study, we reviewed and searched for the keywords "bioelectromagnetic", "photothermal therapy", "MRI" and "nanotranostics" in the scientific databases of Science Direct, PubMed and Google Scholar. About 10 fully relevant articles were found and reviewed.
Results: In most studies, iron oxide was used as a nanoparticle to increase the efficiency of light to heat converting and improve MRI contrast. Along with iron oxide, two derivatives of graphite including graphene oxide and quantum dot graphene were used as coats to reduce toxicity, facilitate transfer, and increase the excitation of nanoparticles by infrared light of the electromagnetic spectrum.
Conclusion: The use of nanotranostic compounds can improves the utilization of electromagnetic waves in both photothermal therapy and MRI imaging and can lead to accurate diagnosis and efficient treatment for cancer cells.
Keywords: "Bioelectromagnetic", "Photothermal Therapy", "MRI" and "Nanotranostics"