Prevalence of Von Willebrand Disease in Women of Reproductive Age with Heavy Menstrual Bleeding in Kashan, Iran During 2019

Prevalence of Von Willebrand Disease in Women of Reproductive Age with Heavy Menstrual Bleeding in Kashan, Iran During 2019
Mohammad Shayestehpour,^1,* Tahereh Abdoli,²
1. Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, I.R. Iran
2. Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, I.R. Iran
Introduction: Von Willebrand disease (VWD) is an inherited disorder of blood clotting in humans. The prevalence of VWD is different among various populations. Prevalence of this disorder in women with menorrhagia is less reported in Asia and Iran. The present study was aimed to determine the prevalence of VWD in women of reproductive age with Heavy Menstrual Bleeding.
Methods: In this cross-sectional study, 160 women in the reproductive age group (15-45 years) with Heavy Menstrual Bleeding (HMB) referred to the Hematology Clinic of Kashan Shahid-Beheshti Hospital during 2019 were participated. Demographic characteristics, clinical testing and physician reported problems of each participate including age, menstrual intervals, having the uterine myoma and polyp were collected using a questionnaire, sonography and physical examination of women by a physician. The laboratory tests included hemoglobin (Hb), ferritin, Iron and total iron-binding capacity (TIBC).
Results: Fifteen patients (9.3%) with severe menstrual bleeding had VWD with the mean age of 34.60±6.85 years. Frequency of the uterine fibroid (Myoma) in women with VWD was significantly more than its rate in patients without VWD (p=0.03). The mean of ferritin among 15 women with and 145 women without VWD was 23±4.28 ug/dL and 30.68±4.46 ug/dL, respectively (P=0.001). The average of serum iron in total participants was 35.3±11.48 ug/dL and VWD patients had a lower iron than those without VWD (P=0.001). There was not a significant difference in TIBC level between women with and without VWD (P=0.6).
Conclusion: VWD accounted for 9.3% of women of reproductive age with heavy menstrual bleeding in Kashan, Iran, which is lower than other regions of Asia.
Keywords: Prevalence, Menorrhagia, Von Willebrand Disease