Correlation of Resistin Serum Level with Fat Mass and Obesity-Associated Gene (FTO) rs9939609 Polymorphism in Obese Women with Type 2 Diabetes

Correlation of Resistin Serum Level with Fat Mass and Obesity-Associated Gene (FTO) rs9939609 Polymorphism in Obese Women with Type 2 Diabetes
Fereidoun Mamaghani,^1,* Maryam Abbasi Majdi,²
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Introduction: The aim of this study was to detect any association of fat mass and obesity-associated (FTO) rs9939609 variant to metabolic and anthropometric parameters and resistin level as adipokines in Iranian obese women with type 2 diabetes mellitus.
Methods: Totally, 42 diabetic and 36 nondiabetic women were selected. The PCR amplicons of FTO gene were sequenced and metabolic, anthropometric parameters and resistin levels were measured.
Results: Serum resistin concentrations were not different between diabetic and non-diabetic subjects (p > 0.05), while resistin level in diabetic group with AA genotype was lower than that with other genotypes in the same group. In rs9939609 SNP adjusted analysis, insulin and HOMA levels were high in AA genotype. While levels of FBS and HbA1c were higher in AA and AT genotypes. In diabetic group, only TG showed significant difference among three genotypes and mean of TG was higher in TA genotype. No significant correlation between resistin and anthropometric and metabolic parameters was found except for DBP in diabetic patients.
Conclusion: There was no significant association between rs9939609 and resistin serum level in type 2 obese diabetic women while percentile ranges (25th, 50th and 75th) of resistin concentrations was high in diabetic group.
Keywords: Rs9939609 polymorphism, FTO gene, Obesity, Type 2 diabetes, Resistin.