Interactions Between Caveolin-1 (rs3807992) Polymorphism and Major Dietary Patterns on Cardio-metabolic Risk Factors Among Obese and Overweight Women

Interactions Between Caveolin-1 (rs3807992) Polymorphism and Major Dietary Patterns on Cardio-metabolic Risk Factors Among Obese and Overweight Women
Faezeh Abaj,¹ Fariba Koohdani,² Masoumeh Rafiee,³ Mir Saeed Yekaninejad,⁴ Khadijeh Mirzaei,^5,*
1. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran
2. Department of Cellular, Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS),
3. Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences (IUMS)
4. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences (TUMS)
5. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS),
Introduction: Caveolin is a cholesterol-dependent essential component located in caveolae. Several studies have been shown CAV-1 SNP related to cardio-metabolic parameters in animal models, however there is few studies in humans. Importantly, there is no study has investigated the interaction between CAV-1 rs3807992 gene and dietary pattern on CVDs risk factors in Iranian population.
Methods: The current cross-sectional study was conducted on 404 overweight and obese females with mean age of 36 years. Dietary intake obtained from FFQ with 147 items. The CAV-1 genotype was measured by the PCR-RFLP method. The anthropometric measurements, serum lipid profile and inflammatory markers were measured.
Results: : There was a significant interaction between CAV-1 rs3807992 and healthy dietary pattern on HDL (P interaction=0.03), TC/HDL (P interaction=0.03) and hs-CRP (P interaction=0.04); in A-allele carriers, higher adherence to the healthy dietary pattern was related to higher level of HDL and lower TC/HDL and hs-CRP. As well as, the significant interactions were observed between CAV-1 rs3807992 and unhealthy dietary pattern in relation to TG (P interaction = 0.001), AST (P interaction = 0.01) and MCP-1(P interaction = 0.01); A-allele carriers were more adherence to the unhealthy dietary pattern to lower levels of TG, AST and MCP-1
Conclusion: : There was a significant interaction between CAV-1 rs3807992 and healthy dietary pattern on HDL (P interaction=0.03), TC/HDL (P interaction=0.03) and hs-CRP (P interaction=0.04); in A-allele carriers, higher adherence to the healthy dietary pattern was related to higher level of HDL and lower TC/HDL and hs-CRP. As well as, the significant interactions were observed between CAV-1 rs3807992 and unhealthy dietary pattern in relation to TG (P interaction = 0.001), AST (P interaction = 0.01) and MCP-1(P interaction = 0.01); A-allele carriers were more adherence to the unhealthy dietary pattern to lower levels of TG, AST and MCP-1
Keywords: Diet; Gene-environment interaction; Caveolin 1; Cardio-metabolic; Personalized medicine