Study of IL-1 Genes Polymorphisms in HBs-Ag Positive and Normal Population of western azerbaijan province

Study of IL-1 Genes Polymorphisms in HBs-Ag Positive and Normal Population of western azerbaijan province
Milad Esmatparast,^1,* Mojtaba Ranjbari,²
1. Department of biology, faculty of science, Islamic Azad University, Urumieh, Iran.
2. Department of biology, faculty of science, Islamic Azad University, Urumieh, Iran.
Introduction: Hepatitis B virus (HBV) is the most common cause of acute and chronic liver disease worldwide, especially in Asia and Africa, with an estimated 350 million people worldwide carrying the virus.Currently, hepatitis B is one of the major health problems in our country and approximately 3 to 8% of the population is somehow involved with the disease.
Methods: Genetic studies on multiple carriers have revealed that human leukocyte antigen (HLA (and various cytokine genes such as:)) 4-TNF-alpha, TNF-gamma, IL-12, IL-18, TGF-beta genes , IL-10, IL-1, IL (associated with HBV sensitivity or its durability or disease severity. Cytokines play an important role in defense against viral infection; IL-1 is also one of the cytokines. The most important members of the IL-1 family include IL-1alpha, IL-1beta, and IL-1RN, all of which are polymorphic, which is a major pro-inflammatory factor and plays a central role in inflammation and viral elimination. Polymorphisms are located in gene regulatory regions and have functional significance with They have a strong role in regulating IL-1 protein production and are associated with the spread of certain diseases. Studies in patients with hepatitis B in Japan have found that a link between IL-1beta polymorphisms and cirrhosis associated with hepatitis B Another study in the same country found that polymorphisms of this gene may be associated with predicting the risk of inflammatory diseases. Some studies on the polymorphisms of the ILRN1 gene also suggest that individuals with the 2-intron allele of the IL-1RN gene may be resistant to HBV infection.
Results: There has also been no study of the association of IL-1alpha polymorphisms with this disease. In this project, the polymorphisms of interleukin 1 genes will be compared in two groups, the first group of patients with known HBs-Ag positive virus infection and the second group of completely healthy individuals without a history of anti-hepatitis B vaccine and They have no previous signs of HBs-Ab, HBc-Ab, hepatitis B.
Conclusion: In general, we have shown in this article that the frequency of alleles of HLA antigen genes and different cytokine genes are related to HBV sensitivity or persistence or severity of disease. There is a direct link between IL-1Beta polymorphisms and hepatitis B-related cirrhosis. However, IL-1RN gene polymorphisms are resistant to hepatitis B in people with Aller 2 IL-1RN intron gene.
Keywords: HBV،HBs-Ab،HBc-Ab،TNF،HLA