Effect of Pore Structure and Morphology of Titanium Foams on Their Biological Behavior in Hard tissue replacements

Effect of Pore Structure and Morphology of Titanium Foams on Their Biological Behavior in Hard tissue replacements
Roghayeh Haghjoo,^1,* Seyed Khatiboleslam Sadrnezhaad,² Nahid Hassanzadeh Nemati ,³
1. Department of Biomedical Engineering, Science and Research branch, Islamic Azad University,
2. Department of Materials science and Engineering, Sharif University of Technology
3. Department of Biomedical Engineering, Science and Research branch, Islamic Azad University
Introduction: Porous titanium has appropriate mechanical and biological properties and may be a promising choice for hard tissue replacements. In this literature, the effect of the pore structure of titanium foams was studied.
Methods: for this purpose, someones were fabricated by powder metallurgy of titanium hydride and by using the space holder method. Three types of space holders were used: sodium chloride with cubic morphology, urea with needle shape, and sphere morphology.
Results: The space holders played a key role in the pore structure as confirmed by microstructural observations. Also, the influence of various pore morphologies on the human primary osteogenic sarcoma cell line (MG63) was evaluated in vitro.
Conclusion: The results show that the proliferation abilities of MG63 were related to different pore morphologies of such porous scaffolds. These results may guide the design for porous titanium in bone defect restoration.
Keywords: titanium foam, pore morphology, biological behavior