- application of curcumin in the treatment of cancers
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dorna dehghani,1 Mojtaba Mortezavi,2,*
1. Department of Biotechnology, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran
2. Department of Biotechnology, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran
- Introduction: The use of traditional medicine in many nations comes from the culture and civilization of the people of that region. They used traditional medicine from far away times as medicine, but with the scientific advancement of peoples of different nations, they brought to the day of chemical medicine and moved away from traditional medicine. But with time and proof of the damage, many of these chemical agents of various nations turned into herbal remedies. Curcumin was isolated and identified for the first time in gross form in 1815 by Vogel and Peltier from the rhizome of the Curcuma longa plant, which was named curcumin. But they failed to identify the composition and chemical formula of this substance. In 2011, the structure and chemical formula of curcumin was identified by Milobedzka and his colleagues, and in 1913 Lampe and Milobedzka synthesized this compound. In 1953, curcumin components were measured and separated by Srinivasan chromatography. The chemical formula of curcumin is dione [3,5-heptadiene-6,1- (methoxyphenyl-3-hydroxyl-4) bis-7,1]. Its hydroxyl groups are essential for antioxidant activity and its methoxy groups for anti-inflammatory and anti-proliferation activities. Curcumin is soluble in water and ether, insoluble in ethanol and dimethyl sulfoxide (DMSO or Dimethyl sulfoxide) and acetone
- Methods: Traditional medicine is a collection of knowledge, skills, and practices based on the definition of the health and medicine organization based on native theories and experiences, whether or not they can be used. Curcumin is a chemical substance that is the cause of the yellow color of saffron and turmeric. For many years, Chinese and Roman doctors have been using this plant to treat various diseases. According to studies, this chemical has various applications in the treatment of various diseases, including Types of cancers, alhob, arthritis, and so on. Accordingly, in this study, which was done by collecting data from various information desks, we studied the anticancer properties of this chemical and how it functions on different cancers.
- Results: Curcumin is used to treat many cancers. If we look at it at the nanoscale, we will see more effective effects.
Correquemin affects the molecular mechanisms of genes and, by their effect on their divisions, prevents their excessive proliferation.
- Conclusion: Thus, according to studies, coccoquine, having an antioxidant effect with an effect on apoptosis, causes the death of cancer cells, or prevents the formation and growth of cancer cells by inhibiting the divisions of a particular gene and preventing the effect of that gene on the target cell.
With more studies on this substance, there is a hope that it will have a good place to treat cancers and treat many cancers.
- Keywords: Curcumin, Cancer, Gene.