Effects of Immediate and Delayed Exercise on balance activities in the Experimental Traumatic Brain Injury in male rats.

Effects of Immediate and Delayed Exercise on balance activities in the Experimental Traumatic Brain Injury in male rats.
Sara Shirazpour,¹ Mohammad Khaksar,^2,* Forouzan Rafie ,³ Sedigeh Amiresmaili,⁴
1. Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran
2. Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran
3. Physiology and Pharmacology Departmaent, Kerman Medical Science University, Kerman, Iran
4. Physiology Departmaent, Bam University of Medical Science, Bam, Iran.
Introduction: Following our previous studies on effects of exercise on brain edema and motor behavior following traumatic brain injury(TBI) , This study was designed to examine changes in effects of immediate and delayed exercise on balance activities in a rat model of in TBI
Methods: which male rats were divided into 5 groups:1) Non-exercise group: (NE): Rats that did not enter the exercise, 2) Sports Group: (24A): the exercise initiated 24 hours after TBI, and continued for 4 weeks , 3) Exercise group: (1WA): the exercise initiated 1 week after TBI, and continued for 4 weeks, 4) Exercise group: (1MB): the exercise initiated 1 month before TBI, and continued for 4 weeks ,5) Exercise group: (1MBA): the exercise initiated 1 month before TBI, and continued for 1 month (4 weeks) after it . TBI was induced by the Marmarou method and evaluate the balance activities by Rotarod test.
Results: The recovery was indicated significantly affected by the exercise in TBI groups. Post hoc analysis demonstrated the improving in balance performance in animals that returned to exercise immediately (24A), and exercise 1MBA were higher (117.71+1.19) (P < 0.05), than those that experienced 1 week delays(1wA) (90.01+1.44) in their return to running, or previous exercise(1MB)(56.25+0.99) (P < 0.05), but not for animals in the No‐exercise group (P < 0.001).
Conclusion: The present results indicated that exercise may cause an improvement of balance activities after TBI.
Keywords: TBI, exercise, balance activities, Rotarod test.