The role of Pl3K/Akt pathway platelet in cardiovascular disease

The role of Pl3K/Akt pathway platelet in cardiovascular disease
Parisa Masoudi Kabir,¹ Mohsen Hamid Pour,^2,*
1. Shahid Beheshti University of Medical Sciences,Tehran,Iran
2. Shahid Beheshti University of Medical Sciences,Tehran,Iran
Introduction: PI3K(phosphatidylinositol 3 kinases)are lipid kinase that generates intracellularly phosphorylated phosphoinositide.PI3K/Akt pathway interacts with proteins for signal transduction, vesicle trafficking and cytoskeletal reorganization. This pathway has a critical role in platelet activation and thrombosis formation.PI3K enzymes at three classes and eight-core isoforms indicate extensive-expression and broad function in mammalian tissues. Cardiovascular diseases are the first causes of mortality and morbidity in all over the world. The main reason for death due to CVD is an ischemic stroke or MI for which arterial thrombosis is a key part.
Methods: Published articles were reviewed if published in the scientific literature between 2000 and 2020. Searches were conducted using Pub Med, Scopus and Google scholar databases. Search terms included MeSH term,” PI3K platelet”, Cardiovascular disease” and “PI3K inhibitor”.
Results: Platelets display an essential role in hemostasis, arterial thrombosis formation, prevention of hemorrhage and support repair at the vascular injury. However, when platelet hyperactivated, they result in arterial thrombosis and subsequently stroke or MI. Inhibition PI3K/Akt pathway in platelet prevents their activation and thrombosis formation accordingly MI doesn’t occur.
Conclusion: Hence, they considered novel anti-thrombotic (PI3K inhibitors) that contrary antiplatelet drugs(ASA, Plavix) don't prolong bleeding time.This review will discuss the evaluation of role PI3K/Akt signalling pathway in cardiovascular disease.
Keywords: PI3k/Akt pathway, platelet activation, cardiovascular disease, PI3k inhibitor, Thrombos formation