Assessing rs4994 polymorphism in the ADRB3 gene and its association with changes in the level of some biochemical factors in the body.

Assessing rs4994 polymorphism in the ADRB3 gene and its association with changes in the level of some biochemical factors in the body.
Sara Farrokhi,^1,* Vajiheh Zarrin pour,²
1. Islamic Azad University Damghan Branch
2. Islamic Azad University Damghan Branch
Introduction: According to WHO reports, Weight Gain is becoming the most serious public health problem and one of the most common causes of deaths in the 21st century, in children and adults worldwide. Weight Gain can have Genetics factors in addition to the acquired causes. Rs4994 polymorphism in ADRβ3 gene is one of the factors increasing body mass index in humans. During this single nucleotide mutation, the G mutant allele replaces A and converts the tryptophan amino acid to arginine. We scanned for the polymorphism of rs4994 (Trp64Arg) in ADRβ3 genes in Iran Tehran population to examine the relationship between this polymorphism and related disorders such as cholesterol levels, LDL, HDL levels and triglycerides.
Methods: We selected 201 adults from the population of men and women in Tehran Iran who were between 18 and 70 years old. Body mass index (BMI) waist/hip ratio were calculated. HDL, LDL, cholesterol and triglyceride concentrations were determined. ADRβ3 polymorphisms (rs4994) were screened by DNA sequencing. According to the World Health Organization, individuals were divided into three categories in terms of body mass index normal weight (BMI < 25 kg/m2), overweight (BMI ≥25.1–29.9 kg/m2) subjects, and obese (≥30 kg/m2).
Results: In people with high body mass index, all biochemical parameters other than HDL increased significantly compared to the control group. Also, people with a BMI of more than 25 kg / m2 had a higher waist circumference than people with normal BMI.
Conclusion: The findings of this study show that BMI (body mass index) was directly associated with increased Waist/hip ratio cholesterol, triglyceride and LDL levels.
Keywords: rs4994, ADRB3, BMI