Impact of interleukin 6 promoter polymorphisms -572 G > C on IL-6 levels and their impacts on the cancer development

Impact of interleukin 6 promoter polymorphisms -572 G > C on IL-6 levels and their impacts on the cancer development
zakieh rostamzadeh khameneh,^1,*
Introduction: The results of relationships between IL-6 polymorphisms including G/C -572 and risk of different types of cancers including leukemia are debatable. Previous meta-analysis of the IL-6 gene offer indications for the existing understanding of the genetic contribution with some cancers.
Methods: We searched (for related studies), in PubMed, Scopus and google scholar published articles up recent year. The strengths of the relationships between IL-6 polymorphisms and numerous cancers risk were reviewed and discussed. We reviewed several case-control surveys involving cancer cases and healthy controls for the analysis.
Results: By means of of constrained qualified data, our study specifically attentive on SNPs of the IL-6 gene, -572 G/C. We perceived minimal significant involvement of -597 G/A polymorphisms with some cancers in the previously published articles on population. Other surveys accentuates the significance of -572G > C polymorphism in elevating IL-6 levels, thus displaying it’s significant in leukemia.
Conclusion: Generally it could be indicate that -572G > C polymorphism detection may be one of the linking associations between IL-6 and leukemia,
Keywords: cancer, gene, polymorphism , leukemia