Does platelet help cancer metastasis?

Does platelet help cancer metastasis?
Parisa Masoudi Kabir,¹ Mohsen Hamid Pour,^2,*
1. Shahid Beheshti University of Medical Sciences,Tehran,Iran
2. Tehran,Shemiran,Tajrish,Gods, square,Darband street,paramedical school
Introduction: Cancer is including a large group of diseases that is characteristic of the cell hyperproliferation, resistance to the apoptosis; induce angiogenesis, acquisition of immortal capable and metastasis. Metastasis is a multistep process that detachment from the primary tumour, entering blood or lymph circulation, survival in circulation, colonization and metastasis formation in distance organs. Metastasis is the main leading of death from cancer and also an enormous challenge in cancer patients’ treatment.
Methods: Published articles were reviewed if published in the scientific literature between 2000 and 2020. Searches were conducted using Pub Med, Scopus and Google Scholar databases. Search terms included Mesh term,”platelet cancer”, and “platelet metastasis” metastasis cancer metastasis”.
Results: Platelets play a major role in the hemostasis and coagulation process. Platelets enfold malignant cells and prevent their cytolysis by NK cells. Release platelet’s α-granule contents (TGF-β), resulted in a transition epithelial to a mesenchymal cell that helps to promote extravasation. Interaction platelet-cancer cells lead to platelet spreading, release their granules and microparticle. Microparticles are extracellular vesicles that contain growth factor, cytokine, mRNA and miRNA. They can induce or repression of different RNA in tumours cells. However, many anti-cancer drugs development but due to high metastasis capable some cancer once remain poor prognosis.
Conclusion: Hence, more knowledge about metastasis mechanism and platelets role in this subject can help to discover ways for a halt it. This review will discuss the platelet role in cancer spreading.
Keywords: Platelet, cancer, metastasis