The effects of increasing plasma cholesterol concentration in high-fat diet of mothers on plasma concentrations of immunoglobulin M and G in male and female neonates of rats.

The effects of increasing plasma cholesterol concentration in high-fat diet of mothers on plasma concentrations of immunoglobulin M and G in male and female neonates of rats.
benyamin khatamsaz,^1,* pardis abolghasemi,²
1. mohammad rasolollah research institute
2. mohammad rasolollah research institute
Introduction: No living thing can survive in its environment without a proper immune system. Animals must defend themselves against microorganisms to survive.Considering the importance of the immune system in maintaining the life of the body therefor there is the nessecity to study the effect of pregnant mother's diet on the newborn's immune system
Methods: In this experimental study, 40 female rats and 20 adult male rats were used.Control group without special treatment, (average cholesterol 2 weeks), (average cholesterol 6 weeks), (high cholesterol 2 weeks), (high cholesterol 6 weeks).After the end of the high-fat diet before pregnancy until the end of breastfeeding Male and female neonates were sampled separately gG and IgM concentrations were measured, then data were analyzed by SPSS software. In all cases, p≤0.05 was considered as a statistically significant level.
Results: The groups (high cholesterol 2 weeks) and (high cholesterol 6 weeks) decreased the mean IgG concentration compared to the control groups (average cholesterol 2 weeks) and (average cholesterol 6 weeks) The groups (high cholesterol 2 weeks) and (high cholesterol 6 weeks) decreased in the mean IgM concentration compared to the control groups, (average cholesterol 2 weeks) and (average cholesterol 6 weeks).
Conclusion: Consumption of high cholesterol by mothers has reduced IgG and IgM levels in male and female rats.
Keywords: High cholesterol, immunoglobulin, neonatal rats