- USING STEM CELLS IN THE TREATMENT OF NEORODEGENERATIVE DISEASES
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Arezoo Montazeri,1,*
1. Shahed Mohandes Vakili
- Introduction: Diseases that target the central nervous system and spinal cord are among the diseases which bring lots of pain and injury.it is estimated that the number of patients with neurodegenerative diseases is increasing, diseases that have not been cured so far. Therefore, finding ways to treat these diseases is crucial.
The human nervous system is so complex and studing neurons in their natural place of their lives logically and morally is really hard. Stem cells have this ability to help to better understand of brain and nervous system and to overcome the obstacles in studing nervous system scientists can find some new ways for curing these types of diseases or just to alleviate the process of diseases spread.
- Methods: The criteria of selecting=the criteria for selecting were the articles that contained information about stem cells and neurodegenerative diseases and how to use stem cells in treatment of these diseases
Resources="stem cells for dummies “written by “Lawrence s.B.Goldsteim"and"Meg Schneider".
"stem cells therapy in neurodegenerative diseases"from"ENZO".
"stem cells for the treatment of neurodegenerative diseases written by “Elise dantuma","Stephanie Merchant"and"Kiminobu Sugaya"
This article was written in less than a month .
- Results: Alzheimer is one of the most common diseases of the dementia but it is diagnosed just after death. This special dementia starts with the destruction of synapses which are involved in memory learning and problem solving. Currently available drugs for treatment of AD are purely for symptoms.
Most of the work currently being done focuses on some approaches. The first type of approach is based on the idea that amyloid plaques or the components that make these plaques are cause of all subsequent injuries.Therefore,if the plaque is removed, the disease can be prevented. Some trials are developing a vaccination strategy to remove plaques.
The second approach is based on ideas about external factors that can cause or exacerbate Alzheimer.
Lack of sufficient dopamine release is the most important cause of Parkinson’s diseases.PD itself is not fatal but complications from the disease can lead to death. Although medications such as"Levodopa"control many of the symptoms to some extent. The disease is incurable and progressive
So far, scientists have had two major approaches to using stem cells or other cells to devise better treatment for Parkinson’s disease .one approach is to try to produce lab-derived neurons in the lab and transplant them to the black body or"striatum"to use for their normal function of supplying the dopamine required by the striatum.
Marrow-derived mesenchymal stem cells(MSCs)have been proposed as a potential treatment for PD."Park “and colleagues investigated the use of MSCs in a PD mouse model to observe potential neuro-protective effect on neuronal loss.
- Conclusion: New therapeutic strategies are being used in many clinical trials, they have significant limitations. Scientists are constantly having difficulty finding new therapeutic solutions, for example, as one of the main approaches to Alzheimer's disease is the removal of amyloid plaques, but some people are partly responsible for the progression of the disease because it is not completely clear.
Using stem cells in the laboratory is an interesting method because it can be examined whether transplantation of healthy cells into Alzheimer's mouse models can replace those cells with horseback cells or rescue damaged models.
The use of stem cells is still very much in the experimental phase, but its use is a new way to see the miracle of this science in the treatment of diseases in the near future.
- Keywords: STEM CELLS, NEURODEGENTAREATIVE, ALZHEIMER’S DISEASES, PARKINSON’S DISEASES