Therapeutic Effect of Hemoderivative Materials in Regenerative Medicine

Therapeutic Effect of Hemoderivative Materials in Regenerative Medicine
Majid Zamani,¹ Parisa Samadi,² Alireza Mohammadzaeh,³ Adel Naimi ,⁴ Yoda Yaghoubi,^5,*
1. Department of Medical Laboratory Sciences, Faculty of Allied Medicine, Gonabad University of Medical Sciences, Gonabad, Iran
2. Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3. Department of Microbiology, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran
4. Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran
5. Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Introduction: Nowadays, in many diseases, regenerative methods are used instead of palliative and restorative therapies. Activation of a reparative cascade is the main physiological response of the body against damaged tissue which is controlled at the cellular level and regulated by bioactive plasma proteins, growth factors, and blood cells or other tissues. Tissue regeneration also proceeds through the inflammatory or exudative, proliferative, and remodeling phases. Hemoderivative materials are used for regenerative medicine which contain blood cells, growth factors, and proteins involved in wound healing. Regardless of the preparation method, use and maintenance of these blood products have some disadvantages and advantages. Used hemoderivative materials in regenerative medicine include platelet-rich plasma (PRP), platelet gel (PG), Platelet-rich fibrin (PRF), and platelet lysate (PL). Autologous conditioned serum (ACS) is a hemoderivative material with anti-inflammatory properties, helping wound and tissue repaired.
Methods: In this review, the last two decades published studies regarding the hemoderivative materials, preparation methods, its compounds and their application in regenerative medicine, tissue engineering and various diseases treatment including type 2 diabetes mellitus, knee injury, cutaneous wound healing, and bone regenaration were studied.
Results: Hemoderivative materials with anti-inflammatory cytokines may help passing the inflammatory phase and enter the wound and tissue healing phase. Additionally, this material contributes in migration, growth and cell proliferation via its growth factors and causes wound healing and damaged nerve tissue repair.
Conclusion: Hemoderivative materials can be considered to treat various wounds and tissue damage such as diabetic foot ulcers because of their different levels of growth factors and anti-inflammatory cytokines.
Keywords: Hemoderivative materials, Blood-derived product, Regenerative Medicine, Growth Factor