A new approach to cancer therapy with lipo-cell

A new approach to cancer therapy with lipo-cell
Maryam Mohammad-Sadeghipour ,¹ Mehrnaz Ghafari,^2,*
1. Department of Clinical Biochemistry, Afzalipoor Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
2. Department of Clinical Biochemistry, Afzalipoor Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
Introduction: Cisplatin is one of the essential drugs for the treatment of solid tumours. In humans and animals, it causes damage to the kidneys, bone marrow, hearing, respiratory system, and DNA of cells, which is one of the causes of infertility. In this study, we used modern medical methods to synthesize artificial cells of the liposome type. Artificial lipo cells were not detected by the immune system and were able to remove tumour cells successfully. It also significantly reduced the side effects of the drug.
Methods: We optimized five formulas for liposomes by modifying the ratio of SPC80 (soy phospholipids to 75% phosphatidylcholine) and cholesterol. Then the best liposomal formulations of PEGylated novels containing SPC80: Cholesterol: DSPE-MPEG (in a ratio of 85: 10: 5) are designed and manufactured to improve as a treatment to achieve better drug efficacy.
Results: Zeta Sizer showed that PEGylated nanoliposomes had a mean diameter of five formulas approximately 100 nm, a zeta potential of -26.03 ± 1.34 mV, and entrapment efficiency of 96.65 ± 3 %. The optimum formulations represented sustained, thermosensitive release, and augmented cellular uptake. The cytotoxic effect of the liposomal drug was higher than that of the free medication drug, which confirmed the efficiency of cellular uptake.
Conclusion: This study suggests that drug carriers such as synthesized nano-liposomes play an essential role in drug efficacy and dosage reduction.
Keywords: lipo-cell, Nano-liposome, Cancer, Cisplatin