• POLYCYSTIC OVARY SYNDROME, ORAL DISEASE AND INFERTILITY
  • Elham Zare,1,*
    1. Boroujerd Islamic Azad University


  • Introduction: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age which has been associated with impaired fertility and negatively affects various health systems. Studies showed that women with PCOS have increased levels of pro-inflammatory cytokines, groups of proteins that help regulate immunity and inflammation. This chronic inflammation can lead to several oral health problems. The aim of this study was to evaluate the association between oral disease and PCOS.
  • Methods: In order to find relevant studies to the research question, an electronic search with time (recent five years, up to 2021) and language (English) restrictions was conducted using PubMed. Most recent studies including case control studies, original research and review articles were selected. Analysis was done and data were synthesized and compiled in a sequential and presentable paradigm.
  • Results: Several studies reported a strong association between periodontal disease and PCOS with a high level of systemic inflammatory markers, including adhesion molecules, TNF-α, IL-1β, IL-6 and monocyte chemoattractant protein. In a cross-sectional study is found that serum C-reactive protein levels were higher in females with newly diagnosed PCOS.
  • Conclusion: From the mentioned results, there seems to be a positive relation between oral disease and PCOS. However, multicenter studies, with larger sample sizes, are to be conducted to establish a clearer and stronger association.
  • Keywords: Infertility, Polycystic ovary syndrome, Oral disease.