• Stem cells and bone regeneration: a review
  • Nafiseh baheiraei,1,* Nayereh Ahmadian,2
    1. Tissue Engineering & Applied Cell Sciences Division, Department of Anatomical Sciences, Faculty of Medical science, Tarbiat Modares University, Tehran, Iran
    2. Department of Bio-Computing, Faculty of Interdisciplinary Science and Technologies, Tarbiat Modares University, Tehran, Iran


  • Introduction: Bone defects that is caused by disease and traumas have become a clinical challenge which seriously affect the health and life quality especially amongst the elderly. Cell therapy which has gained an increasing attention toward itself lately, has offered new methods to treat incurable diseases. Stem cells are able to improve angiogenesis and prevent fibrosis that leads to heal the damaged tissue. Hence, they have an important role in tissue regeneration and repair. The objective of this work is to review the recent researches on stem cell therapy for bone regeneration; compared with other current treatments.
  • Methods: Electronic databases were searched.
  • Results: Implantation of cells in combination with scaffolds results in greater bone regeneration compared with transplantation of cells alone. Mesenchymal stem cells (MSCs) seem more acceptable to be used in clinical trials compare to other stem cells for bone repair.
  • Conclusion: Among various cells used for cell therapy, MSCs have therapeutic potential holding several advantages over conventional treatments in bone regeneration. However, more researches is needed to understand the mechanisms underlying their therapeutic efficacy which could direct clinical decision-making.
  • Keywords: Bone regeneration, Cell therapy, Mesenchymal stem cells, Scaffolds