• Histometrical evaluation of lead acetate effects on kidney and testes of male diabetic rats due to cinnamon extract administration
  • Fattahian Rahmatollah,1 Forouhar Majd Kianoush,2 Badkoubi Amirhossein,3,* Changaniyan Khorasgani Zahra,4
    1. Associate Professor, Department of Basic Sciences, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran
    2. Student of Veterinary Medicine, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran
    3. Student of Veterinary Medicine, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran
    4. Student of Veterinary Medicine, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran


  • Introduction: Chronic hyperglycemia that is known as a hallmark of diabetes, have involved a majority of peoples around the world. The cytotoxic effect of Lead acetate that is released in water and the environment of Developed and under-developing countries, has been proved. Cinnamon contains natural antioxidant extracts. It has been known for it's major component, Cinnamaldehyde. Therefore, we investigate on Histometrical effects of lead acetate on testes and kidneys of male rats treated with cinnamon extract.
  • Methods: 48 male rats that have been weighted in a range between 200±20gm, were used in this investigation. All animals’ examination were carried out under the protocols that approved by the veterinary faculty of Shahrekord university. At the end of this examination, the kidneys and testes of rats were collected and processed. All specimens were stained by H&E staining. After the data collection, they have been analyzed by the latest version of SPSS with consideration of P<0.05 significance.
  • Results: Histometrical analysis of cinnamon extract administrated groups, indicates significant tissue changes. Also, this investigation approves predominant Histometrical changes in examined tissues due to oral administration of lead acetate.
  • Conclusion: The potential role of cinnamon in management of the hyperglycemia has been indicated in many in vitro studies on both human and animal cases. Cinnamon treats diabetes by activating insulin-receptor-kinase and inhibiting insulin-receptor-phosphatase, resulting in a maximal response of insulin-receptor-phosphatase and subsequently increase insulin sensitivity. The enzyme; insulin-receptor-kinase; facilitates insulin binding to cells and another enzyme, insulin-receptor-phosphatase, can cease this process.
  • Keywords: Cinnamon, Histometrical Investigation, Lead acetate, Kidney, Testes