• Bioinformatics evaluation of the rs185294556 signaling pathway in VEGFA gene related to has-mir-24-3p- in individuals with COVID-19
  • Haniyeh Fooladinezhad,1,*
    1. Department of genetics faculty of sciences shahrekord branch Islamic azad university, shahrekord iran


  • Introduction: CIVID-19 infectious disease is caused by the SARS-COV-2 virus, which is an acute respiratory virus. Although research on the disease is ongoing, findings have shown that altered gene expression as well as biomarkers such as miRNA and SNP can cause the disease. Studies and articles have shown that the VEGFA gene is highly expressed in people with COVID-19, which increases vascular permeability and fluid accumulation in the lungs, which is associated with inflammation. This gene is involved as one of the key and candidate genes in this disease.
  • Methods: For this reason, we used the NCBI, Mirbase, mirSNP, miRWALK2, DAVID, and KEGG sites to find bioinformatics information on miRNA and SNP genes and biomarkers.
  • Results: Has-miR-24-3p is predicted to target (G> T) rs4073460 in the 3 UTR region of the VEGFA gene in the COVID-19 inflammatory cycle inhibition pathway.
  • Conclusion: In the present project, according to bioinformatics predictions, has-miR-24-3p has a high binding power to VEGFA gene and if it binds, due to the negative regulatory function of this microRNA, the expression of the desired gene is expected to decrease and lead to decrease Vascular permeability, reduced fluid accumulation in the lungs and inflammation. This issue needs more laboratory studies.
  • Keywords: Keyword: COVID-19, miRNA, VEGFA, has-miR-24-3p, SNP