• A Comparative Study on the Effects of Nephrotoxicity in Teicoplanin and Linezolid Injection in Patients with Vancomycin-Resistant Gram-positive Infections Admitted to Selected Education Centers of Alborz University of Medical Sciences in 1396
  • sara khodayar,1 iraj javadi,2,* mahdi azimian zavareh,3
    1. Department of Toxicology, college of Pharmacy , Shahreza branch, Islamic Azad University, Shahreza, Iran
    2. Department of Toxicology, college of Pharmacy , Shahreza branch, Islamic Azad University, Shahreza, Iran
    3. Department of Developmental Biology, college of Basic Sciences , Science and Research branch, Islamic Azad University, Tehran, Iran


  • Introduction: Teicoplanin and Linezolid have an impact on the spectrum of gram-positive bacteria resistant to vancomycin. According to previous studies, there are conflicting reports of the effects of these two drugs on the hepatorenal and thrombocytopenic systems, The aim of this study was to evaluate the effects of nephrotoxicity in Teicoplanin and linezolid injection in patients with vancocomycin resistant gram positive infections in selected educational centers of Alborz University of Medical Sciences in 1396.
  • Methods: Randomized sampling was performed from patients hospitalized in different hospitals of Alborz University of Medical Sciences (Shahid Madani, Shahid Rajai, Shahid Bahonar, Kamali) with vanocomycin-resistant gram-positive bacterial infections. Samples were taken 10 consecutive days and measure renal markers such as urea, creatinine, glucose filtration rate (GFR). On the other hand, two important markers of kidney damage of albumin and Kim-1 were also evaluated by Kite Eliza for confirmation of renal markers. 123 patients were divided into six groups based on the use of linezolide or Teicoplanin and the age group (three age ranges: 18-29 years old, ages 30- 49, and more than 50 years old). The control group was also considered in all three age groups including healthy people who did not receive any medication.
  • Results: The data of the study showed that The data of the study showed that Teicoplanin and linezolid in people over 50 years of age had an effect on GFR, thrombocytopenia and urea levels, and these effects were less pronounced in the age group of 30-49 years. On the other hand, in two age groups of 30 to 49 years and more than 50 years, after ten days of using these antibiotics, both drugs have a significant effect on the amount of two kidney damage biomarkers of albumin and Kim-1. Teicoplanin and linezolid in people over 50 years of age had an effect on GFR and these effects were less pronounced in the age group of 30-49 years. On the other hand, in two age groups of 30 to 49 years and more than 50 years, after ten days of using these antibiotics, both drugs have a significant effect on the amount of two kidney damage biomarkers of albumin and Kim-1.
  • Conclusion: The results of this study indicate the prognosis of kidney damage in long-term administration of drugs and should be given more precisely at the clinic according to the age category of subjects and the field of kidney disease, dosage and duration of use of these antibiotics.
  • Keywords: Ticoplanin, Linzolide, Nephrotoxicity, Albumin, Kim-1, vancomycin