مقالات پذیرفته شده در پنجمین کنگره بین المللی زیست پزشکی
Evaluation of genetic causes of recurrent miscarriage
Evaluation of genetic causes of recurrent miscarriage
Zahra Sadat Aghaei Shahri,1,*
1. Zahra Sadat Aghaei Shahri Member of the Research Committee of the Islamic Azad University of Mashhad. Iran
Introduction: Recurrent miscarriage (RM) is a common fertility complication that refers to three or more consecutive miscarriages that occur before the twentieth week of pregnancy. Chromosomes are located in a prokaryotic cell or in the nucleus of a eukaryotic cell and contain DNA. Genetic defects are caused by genetic mutations that occur in the fetus. Any detectable and inherited change in genetic material that causes a change in genotype and is passed on to daughter cells and future generations is called a mutation. Mutations may be inherited from the parent genome or created in the womb. Polymorphisms are regular and occur in a group between two or more discontinuous genotypes.
Methods: Articles reviewed in databases published from 2012 to 2021. Search by keywords recurrent miscarriage, genetic defects, chromosomes, polymorphisms, genetic mutations. 6 articles from google scholar database and 9 articles from database pubmed were selected. 4 articles from google scholar database and 6 articles from pubmed database were deleted due to lack of connection with the title of the items and finally 5 articles were reviewed.
Results: In 2 studies, it was found that chromosomal abnormalities of displacement and inversion play an important role in RM, which accounts for 50% of RM in the first trimester and affects the morphological y, y histology, and secretion of hormones and proteins. Put. Leads to hypoplasia, placental abruption, vascular disorders and eventually miscarriage.
In 3 studies mutations in genes associated with Smith-Lamelie Opitz syndrome, congenital methemoglobinemia and sickle cell anemia, myotonic dystrophy, tanatophoretic dysplasia and type II osteogenesis imperfecta and methylene-tetrahydrofolate-reductase mutation (VA) M16 (TF) And factor II G20210A is mentioned which leads to RM.
Based on 3 studies, we found that 53 genetic polymorphisms of 37 genes affect the creation (RM).
Based on 2 studies, we found that genes associated with thrombophilia, cytokines, hormone receptors, and genes associated with angiogenesis are prone to RM, and abnormal placental function, hyperactive immune responses, and metabolic disorders are among the causes of RM.
In 1 study found that NLRP2 or NLRP7 malfunction leads to RM. SNPs in some genes and overexpression of miRNAs (microRNA-575) can also cause RM.
Conclusion: Given that one of the most common causes of recurrent miscarriage can be genetic defects, chromosomes, polymorphisms, genetic mutations, and genetic problems and recurrent miscarriage threaten both couples. Therefore, in people who have had recurrent miscarriages, it is necessary to refer to a geneticist and check the chromosomes of man and woman by genetic testing and karyotype determination.