• The effect of carbamazepine in the treatment of Alzheimer's
  • Ali Khanifar,1,*
    1. Kurdistan university of medical sciences


  • Introduction: As you know, in Alzheimer's disease, two complications are most prominent, one is amyloid plaques and the other is hippocampal analysis. A US university study of amyloid plaques found plaques in people with dementia, but surprisingly, people with no history of dementia had amyloid plaques.According to this study, it can be concluded that amyloid plaques are an accelerating factor in Alzheimer's disease but not a 100% factor. In this research, a new method is used in the treatment of Alzheimer's, which will also use seizure drugs, especially carbamazepine, as a treatment for Alzheimer's. In Alzheimer's disease, neurons connected to the hippocampus become contracted and lose their connection to the hippocampus, causing the hippocampus to begin to degenerate over time. Among the drugs used to treat seizures, carbamazepine causes a strong memory in people who use it for a limited time, and when they stop taking it, they experience a kind of memory loss.
  • Methods: Carbamazepine is a sodium channel blocker. In fact, this action causes the humidity of the brain waves between all parts of the brain, which takes the neurons out of the curved state in all parts of the brain and returns them to their part, and prevents the failure of the desired part, especially the hippocampus.To prove this theory, two mice are needed in the laboratory, one young and the other 5 years old, which is equivalent to an old human. First, we put the young mouse in a tortuous corridor and we see that the young mouse leaves this corridor with 2 routing times, but another mouse, which is the same age as an old human, leaves the ability to leave after 6 to 7 routing times. It has this corridor, but by injecting carbamazepine into old mice, I see that over time, the old mouse's ability to get out of the corridor gets better and better.
  • Results: In fact, taking carbamazepine by Alzheimer's patients will prevent hippocampal resorption, and this is done by reversing neurons. Because brain cells, especially the hippocampus, will not be able to repair, treatment with carbamazepine should be started as soon as possible.
  • Conclusion: As mentioned, this drug is used to treat seizures that, due to the balance and humility that it shows in different parts of the brain, prevents the breakdown of the hippocampus, which plays a key role in Alzheimer's disease.The drug also boosts memory in some patients and interrupts memory loss.
  • Keywords: Carbamazepine - Alzheimer-Amyloid plaques -Hippocampal - Memory loss