Frequency of (rs34713741)-254C>T polymorphism of Selenoprotein S Gene in Patients with Type 2 Diabetes and Correlation with Selenoprotein S, Glucose and Oxidative Stress Levels
Frequency of (rs34713741)-254C>T polymorphism of Selenoprotein S Gene in Patients with Type 2 Diabetes and Correlation with Selenoprotein S, Glucose and Oxidative Stress Levels
alireza farrahi,1,*Mohsen Firoozrai,2Mohammad Hossein Hasani,3Ali Asghar Ahmadi,4Akram Mehrzad Selakjani,5Masoud Tahani,6
1. Student, Clinical biochemistry, Medical faculty, Shahrood Azad University, Email: alirezafarrahi95@gmail.com, ORCID iD: 0000-0002-3112-8918. 2. professor, Clinical biochemistry Department, Medical faculty, Shahrood Azad university. 3. Department of Interal medicine, Islamic Azad university, Shahrood Branch, Shahrood, Iran 4. Biochemistry Laboratory, North Reserch Center-pasteur Institue of Iran, Amol, Mazandaran, Iran. 5. Student, Clinical biochemistry, Medical faculty, Shahrood Azad University, ORCID iD: 0000-0001-7938-6759. 6. Student, Clinical biochemistry, Medical faculty, Shahrood Azad university.
Introduction: It is widely accepted that type 2 diabetes is a metabolic disorder, the main characteristic of which is insulin resistance and gradual beta-cell dysfunction. It seems that oxidative stress and low plasma selenoprotein (SelS) levels are associated with an increased risk of diabetes. This study aimed to evaluate rs34713741 polymorphism in a population of diabetics and its relationship with glucose, SelS, and oxidative stress levels.
Methods: This case-control research was performed on 122 patients with type 2 diabetes and 106 healthy individuals from the Diabetes clinics in Tehran (Iran). We determined the levels of glucose, malondialdehyde (MDA), total antioxidant capacity (TAC), and HbA1C and measured lipid profile and SelS levels. The (rs 34713741)-254C
Results: In this study, there was a significant relationship between CT and TT genotype of (rs 34713741)-254C
Conclusion: According to the results of the present study, there was a relationship between rs34713741 polymorphism and type 2 diabetes. In addition, the T allele of the rs34713741 polymorphism had an impact on patients with type 2 diabetes.