Changing of Protein Concentration and Colloid Osmotic Pressure in Glomerular Capillaries Following a Decrease in Albumin-Globulin Ratio During Renal Filtration
Changing of Protein Concentration and Colloid Osmotic Pressure in Glomerular Capillaries Following a Decrease in Albumin-Globulin Ratio During Renal Filtration
Introduction: Renal Filtration, based on Starling Equation, is dependent on Hydrostatic Pressure (HP) and Colloid Osmotic Pressure (COP) between two sides of glomerular membrane in renal corpuscles. COP is related to plasma Total Protein Concentration (TP) and Albumin-Globulin Ratio (A/G). In this study, for different A/G, the mathematical relationship between COP and TP was developed in-vitro. Differential equation for changing COP and TP in glomerular capillaries was analyzed with numerical methods.
Methods: The results indicate that A/G affects the variations of TP and Net Filtration Pressure (NFP) in glomerular capillaries. The effect of A/G is also related to Mean Arterial Pressure ( P), Inlet Plasma Flow (J), and Filtration Coefficient (K)
Results: For any value of S=K P/J, the variation of TP and NFP is inversely related to A/G.
Conclusion: Not only is NFP related to A/G, but also with a decrease in S, the filtration takes place along the glomerular capillary. With increasing S, the filtration is limited in the middle of capillaries, because pressures on each sides of glomerular membrane are approaching equilibrium