Nayereh Abdali,1,*Tahereh Abdali,2
1. 1* MSc of Medical Biotechnology, Faculty of advance Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran 2. MSc student in Plant Systematics, Yasouj University, Yasouj, Iran
Introduction: One of the problems of cancer patients is drug resistance. Several mechanisms are involved in the development of drug resistance, such as drug withdrawal from the ATP-dependent pump. P-gp is the most common family of ABC pumps that are encoded by the MDR1 gene and is the most important cause of drug resistance. Signaling pathways affect various biological factors in the body and the cell. Therefore, one of their goals could be MDR1 drug resistance pumps, which are regulated by the signaling pathways of this pump.
Methods: This is a review study Collected by reviewing articles related to the Signaling pathway and its effect on drug resistance MDR1 with the keywords "MDR1" OR "signaling pathway" and "P-gp" OR "signaling pathway" from 2017 onwards, from Google Scholar and Pubmed it has been compiled and written. 52 articles were collected, that of these 7 articles were excluded because of lack of subject relevance and only 45 studies were used. The inclusion criteria were all articles that examined the effect of different signaling pathways on MDR1 drug resistance.
Results: Different studies have shown that Numerous signaling pathways affect the performance regulation of MDR1 drug resistance pumps. VEGF, PI3k/AKT, FGFR, NF-KB, wnt, Raf-MAPK, MEK /ERK, JAK2/STAT3, MAPK, PXR, FZDZ/wnt, TGFB, Cjun-jNK are among the most important signaling pathways. that can reduce or increase MDR1 activity and expression.
Conclusion: Multiple signaling pathways affect drug resistance as a major challenge in the treatment of cancer patients. The MDR1 pump can be regulated to signaling pathways that have a reducing effect on it, such as the ERK signaling pathway, reducing its expression. As a result, treatment failure and drug resistance in cancer patients are reduced and the effectiveness of chemotherapy drugs is increased.
Keywords: MDR1, Drug resistance, Signaling pathway